Postdoctoral position in X-ray crystallography, NMR, cryo-EM, single molecule tracking, cell biology 1. Researcher/Postdoc level

National Institutes of Health

勤務地
Others - Outside of Japan/ Work at home etc. 
給与
非掲載

こんな仕事です

The National Institutes of Health (NIH) is the biggest biomedical research facility located in Bethesda, Maryland, U. S. A. I have been directing an independent research program at the National Cancer Institute (NCI) within NIH for the past 20 years.
Research title: Investigating the architecture and function of centrosomal self-assemblies using X-ray crystallography, NMR, cryo-EM, single molecule tracking, or classical cell biology/biochemistry
The architecture of a cell is established through varying degrees of hierarchical organizations from single molecules to macromolecular assemblies. Investigating how these molecules interact with one another to form a higher-order structural entity that offers a new biological function is a key step to unlocking the mystery of life. We are mainly interested in understanding the molecular bases of how the physicochemical properties of pericentriolar scaffold proteins drive the formation of micron-scale self-assemblies with distinct cellular functions. Recently, we found that human polo-like kinase 4, a key regulator of centriole duplication, forms a high M.W. complex with centrosomal scaffold proteins, which cooperatively self-assemble into a higher-order architecture around a centriole in a concentration-dependent manner. Notably, a failure in these events can result in abnormal centrosome numbers, improper spindle formation, and chromosome missegregation that ultimately lead to the development of various human diseases, including cancer, ciliopathy, and microcephaly. Thus, we aim to elucidate the molecular mechanism underlying the assembly of the complex pericentriolar architecture to ultimately understand the etiology of centrosome-associated human diseases.
Fellows who have an expertise in structural biology (X-ray or NMR), single molecule tracking, cryo-EM, or cell biology/biochemistry with a keen interest in characterizing the biological function and physicochemical properties of pericentriolar self-assemblies are encouraged to apply.
My lab is located at 9000 Rockville Pike, Bethesda, Maryland 20892. U. S. A. For information about our research program, please visit the link below.
https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee
Two recent papers:
1. Kim TS, et al., Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat. Comm. 10:1151
2. Park JE, et al., Phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat. Comm. 10:4959
Number of positions available: 2
Starting date: As soon as possible
Application deadline: May 31, 2020

募集要項

  • 応募条件
    Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab or have achieved the degree less than 2 years ago.
    Fellows who have an expertise in structural biology (X-ray or NMR), single molecule tracking, cryo-EM, or classical cell biology/biochemistry with a keen interest in characterizing the biological function and physicochemical properties of pericentriolar self-assemblies are encouraged to apply.
  • 勤務地
    Others - Outside of Japan/ Work at home etc. 
  • 給与
    非掲載

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